Luca Digiacomo

Physicist by training, I approached to life and health siences just after graduating. My research activity mainly focuses on the computational aspects of the lab's studies on protein-nanomaterial interactions. I enjoy coding custom scripts for statistical data analysis, curve fitting and image processing tools. My main project aims to the development of nanoparticle-enabled blood tests for the early detection of pancreatic cancer.

Some publications with our group

Microfluidic Formulation of DNA-Loaded Multicomponent Lipid Nanoparticles for Gene Delivery Erica Quagliarini, Serena Renzi, Luca Digiacomo, Francesca Giulimondi, Barbara Sartori, Heinz Amenitsch, Valentina Tassinari, Laura Masuelli, Roberto Bei, Lishan Cui, Junbiao Wang, Augusto Amici, Cristina Marchini, Daniela Pozzi, Giulio Caracciolo Published in Pharmaceutics, August 2021 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

A Proteomic Study on the Personalized Protein Corona of Liposomes. Relevance for Early Diagnosis of Pancreatic DUCTAL Adenocarcinoma and Biomarker Detection Luca Digiacomo, Francesca Giulimondi, Daniela Pozzi, Alessandro Coppola, Vincenzo La Vaccara, Damiano Caputo, Giulio Caracciolo Published in Journal of Nanotheranostics, June 2021 (see publication) Research themes: Liposomes and lipid nanoparticles, Nanomaterials for cancer detection Type: Paper

Protein corona profile of graphene oxide allows detection of glioblastoma multiforme using a simple one-dimensional gel electrophoresis technique: a proof-of-concept study Riccardo Di Santo, Erica Quagliarini, Luca Digiacomo, Daniela Pozzi, Angelina Di Carlo, Damiano Caputo, Andrea Cerrato, Carmela Maria Montone, Morteza Mahmoudi, Giulio Caracciolo Published in Biomaterials science, March 2021 (see publication) Research themes: Type: Paper

Optimal centrifugal isolating of liposome–protein complexes from human plasma Luca Digiacomo, Francesca Giulimondi, Anna Laura Capriotti, Susy Piovesana, Carmela Maria Montone, Riccardo Zenezini Chiozzi, Aldo Laganà, Morteza Mahmoudi, Daniela Pozzi, Giulio Caracciolo Published in Nanoscale Advances, March 2021 (see publication) Research themes: Liposomes and lipid nanoparticles Type: Paper

Personalized Graphene Oxide-Protein Corona in the Human Plasma of Pancreatic Cancer Patients Riccardo Di Santo, Luca Digiacomo, Erica Quagliarini, Anna Laura Capriotti, Aldo Laganà, Riccardo Zenezini Chiozzi, Damiano Caputo, Chiara Cascone, Roberto Coppola, Daniela Pozzi, Giulio Caracciolo Published in Frontiers in Bioengineering and Biotechnology, May 2020 (see publication) Research themes: Graphene Oxide and hybrid nanomaterials, Nanomaterials for cancer detection Type: Paper

A mechanistic explanation of the inhibitory role of the protein corona on liposomal gene expression Sara Palchetti, Luca Digiacomo, Francesca Giulimondi, Daniela Pozzi, Giovanna Peruzzi, Gianmarco Ferri, Heinz Amenitsch, Francesco Cardarelli, Morteza Mahmoudi, Giulio Caracciolo Published in Biochimica et Biophysica Acta (BBA) - Biomembranes, March 2020 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

Impact of the protein corona on nanomaterial immune response and targeting ability Luca Digiacomo, Daniela Pozzi, Sara Palchetti, Alessandra Zingoni, Giulio Caracciolo Published in Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, January 2020 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles, Graphene Oxide and hybrid nanomaterials Type: Review

Interplay of protein corona and immune cells controls blood residency of liposomes Francesca Giulimondi, Luca Digiacomo, Daniela Pozzi, Sara Palchetti, Elisabetta Vulpis, Anna Laura Capriotti, Riccardo Zenezini Chiozzi, Aldo Laganà, Heinz Amenitsch, Laura Masuelli, Giovanna Peruzzi, Morteza Mahmoudi, Isabella Screpanti, Alessandra Zingoni, Giulio Caracciolo Published in Nature communications, August 2019 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

Converting the personalized biomolecular corona of graphene oxide nanoflakes into a high-throughput diagnostic test for early cancer detection Massimiliano Papi, Valentina Palmieri, Luca Digiacomo, Francesca Giulimondi, Sara Palchetti, Gabriele Ciasca, Giordano Perini, Damiano Caputo, Maria Cristina Cartillone, Chiara Cascone, Roberto Coppola, Anna Laura Capriotti, Aldo Laganà, Daniela Pozzi, Giulio Caracciolo Published in Nanoscale, July 2019 (see publication) Research themes: Graphene Oxide and hybrid nanomaterials, Nanomaterials for cancer detection Type: Paper

The biomolecular corona of gold nanoparticles in a controlled microfluidic environment Luca Digiacomo, Sara Palchetti, Francesca Giulimondi, Daniela Pozzi, Riccardo Zenezini Chiozzi, Anna Laura Capriotti, Aldo Laganà, Giulio Caracciolo Published in Lab on a Chip, June 2019 (see publication) Research themes: Nanocarriers for drug and gene delivery, Nanomaterials for cancer detection Type: Paper

Disease-specific protein corona sensor arrays may have disease detection capacity Giulio Caracciolo, Reihaneh Safavi-Sohi, Reza Malekzadeh, Hossein Poustchi, Mahdi Vasighi, Riccardo Zenezini Chiozzi, Anna Laura Capriotti, Aldo Laganà, Mohammad Hajipour, Marina Di Domenico, Angelina Di Carlo, Damiano Caputo, Haniyeh Aghaverdi, Massimiliano Papi, Valentina Palmieri, Angela Santoni, Sara Palchetti, Luca Digiacomo, Daniela Pozzi, Kenneth S Suslick, Morteza Mahmoudi Published in Nanoscale Horizons, June 2019 (see publication) Research themes: Liposomes and lipid nanoparticles, Nanomaterials for cancer detection Type: Paper

Effect of molecular crowding on the biological identity of liposomes: an overlooked factor at the bio-nano interface Luca Digiacomo, Francesca Giulimondi, Morteza Mahmoudi, Giulio Caracciolo Published in Nanoscale Advances, May 2019 (see publication) Research themes: Liposomes and lipid nanoparticles Type: Paper

Exploitation of nanoparticle-protein interactions for early disease detection Massimiliano Papi, Valentina Palmieri, Sara Palchetti, Daniela Pozzi, Luca Digiacomo, Elia Guadagno, Marialaura del Basso De Caro, Marina Di Domenico, Serena Ricci, Roberto Pani, Morteza Mahmoudi, Angelina Di Carlo, Giulio Caracciolo Published in Applied Physics Letters, April 2019 (see publication) Research themes: Liposomes and lipid nanoparticles, Nanomaterials for cancer detection Type: Paper

Protein corona fingerprints of liposomes: New opportunities for targeted drug delivery and early detection in pancreatic cancer Sara Palchetti, Damiano Caputo, Luca Digiacomo, Anna Laura Capriotti, Roberto Coppola, Daniela Pozzi, Giulio Caracciolo Published in Pharmaceutics, January 2019 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles, Nanomaterials for cancer detection Type: Paper

Microfluidic manufacturing of surface-functionalized graphene oxide nanoflakes for gene delivery Riccardo Di Santo, Luca Digiacomo, Sara Palchetti, Valentina Palmieri, Giordano Perini, Daniela Pozzi, Massimiliano Papi, Giulio Caracciolo Published in Nanoscale, January 2019 (see publication) Research themes: Nanocarriers for drug and gene delivery, Graphene Oxide and hybrid nanomaterials Type: Paper

Cationic lipid/DNA complexes manufactured by microfluidics and bulk self-assembly exhibit different transfection behavior Luca Digiacomo, Sara Palchetti, Daniela Pozzi, Augusto Amici, Giulio Caracciolo, Cristina Marchini Published in Biochemical and biophysical research communications, September 2018 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

Improving the accuracy of pancreatic cancer clinical staging by exploitation of nanoparticle-blood interactions: a pilot study Damiano Caputo, Maria Cristina Cartillone, Chiara Cascone, Daniela Pozzi, Luca Digiacomo, Sara Palchetti, Giulio Caracciolo, Roberto Coppola Published in Pancreatology, September 2018 (see publication) Research themes: Liposomes and lipid nanoparticles, Nanomaterials for cancer detection Type: Paper

Brain targeting by liposome–biomolecular corona boosts anticancer efficacy of temozolomide in glioblastoma cells Antonietta Arcella, Sara Palchetti, Luca Digiacomo, Daniela Pozzi, Anna Laura Capriotti, Luigi Frati, Maria Antonietta Oliva, Georgia Tsaouli, Rossella Rota, Isabella Screpanti, Morteza Mahmoudi, Giulio Caracciolo Published in ACS Chemical Neuroscience, July 2018 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

Human biomolecular corona of liposomal doxorubicin: The overlooked factor in anticancer drug delivery Giulio Caracciolo, Sara Palchetti, Luca Digiacomo, Riccardo Zenezini Chiozzi, Anna Laura Capriotti, Heinz Amenitsch, Paolo Maria Tentori, Valentina Palmieri, Massimiliano Papi, Francesco Cardarelli, Daniela Pozzi, Aldo Laganà Published in ACS applied materials & interfaces, June 2018 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

Dynamic fingerprinting of sub-cellular nanostructures by image mean square displacement analysis Luca Digiacomo, Francesca D’autilia, William Durso, Paolo Maria Tentori, Giulio Caracciolo, Francesco Cardarelli Published in Scientific reports, November 2017 (see publication) Research themes: Nanocarriers for drug and gene delivery Type: Paper

An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles Luca Digiacomo, Francesco Cardarelli, Daniela Pozzi, Sara Palchetti, Michelle A. Digman, Enrico Gratton, Anna Laura Capriotti, Morteza Mahmoudi, Giulio Caracciolo Published in Nanoscale, October 2017 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

Clinically approved PEGylated nanoparticles are covered by a protein corona that boosts the uptake by cancer cells Massimiliano Papi, Damiano Caputo, Valentina Palmieri, Roberto Coppola, Sara Palchetti, Francesca Bugli, Cecilia Martini, Luca Digiacomo, Daniela Pozzi, Giulio Caracciolo Published in Nanoscale, June 2017 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

Impact of the biomolecular corona on the structure of PEGylated liposomes Luca Digiacomo, Daniela Pozzi, Heinz Amenitsch, Giulio Caracciolo Published in Biomaterials science, June 2017 (see publication) Research themes: Liposomes and lipid nanoparticles Type: Paper

Influence of dynamic flow environment on nanoparticle-protein corona: From protein patterns to uptake in cancer cells Sara Palchetti, Daniela Pozzi, Anna Laura Capriotti, Giorgia La Barbera, Riccardo Zenezini Chiozzi, Luca Digiacomo, Giovanna Peruzzi, Giulio Caracciolo, Aldo Laganà Published in Colloids and Surfaces B: Biointerfaces, May 2017 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

Manipulation of lipoplex concentration at the cell surface boosts transfection efficiency in hard-to-transfect cells Sara Palchetti, Daniela Pozzi, Cristina Marchini, Augusto Amici, Cristina Andreani, Caterina Bartolacci, Luca Digiacomo, Valentina Gambini, Francesco Cardarelli, Carmine Di Rienzo, Giovanna Peruzzi, Heinz Amenitsch, Rocco Palermo, Isabella Screpanti, Giulio Caracciolo Published in Nanomedicine: Nanotechnology, Biology and Medicine, February 2017 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

In vivo protein corona patterns of lipid nanoparticles Augusto Amici, Giulio Caracciolo, Luca Digiacomo, Valentina Gambini, Cristina Marchini, Martina Tilio, Anna Laura Capriotti, Valentina Colapicchioni, Roberto Matassa, Giuseppe Familiari, Sara Palchetti, Daniela Pozzi, Morteza Mahmoudi, Aldo Laganà Published in RSC advances, January 2017 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

A protein corona-enabled blood test for early cancer detection Damiano Caputo, Massimiliano Papi, Roberto Coppola, Sara Palchetti, Luca Digiacomo, Giulio Caracciolo, Daniela Pozzi Published in Nanoscale, January 2017 (see publication) Research themes: Liposomes and lipid nanoparticles, Nanomaterials for cancer detection Type: Paper

Development of an image Mean Square Displacement (iMSD)-based method as a novel approach to study the intracellular trafficking of nanoparticles Luca Digiacomo, Michelle A. Digman, Enrico Gratton, Giulio Caracciolo Published in Acta biomaterialia, September 2016 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

Nanoparticles-cell association predicted by protein corona fingerprints Sara Palchetti, Luca Digiacomo, Daniela Pozzi, Giovanna Peruzzi, Elisa Micarelli, Morteza Mahmoudi, Giulio Caracciolo Published in Nanoscale, June 2016 (see publication) Research themes: Liposomes and lipid nanoparticles Type: Paper

Personalized liposome–protein corona in the blood of breast, gastric and pancreatic cancer patients Valentina Colapicchioni, Martina Tilio, Luca Digiacomo, Valentina Gambini, Sara Palchetti, Cristina Marchini, Daniela Pozzi, Sergio Occhipinti, Augusto Amici, Giulio Caracciolo Published in The international journal of biochemistry & cell biology, June 2016 (see publication) Research themes: Liposomes and lipid nanoparticles, Nanomaterials for cancer detection Type: Paper

The intracellular trafficking mechanism of Lipofectamine-based transfection reagents and its implication for gene delivery Francesco Cardarelli, Luca Digiacomo, Cristina Marchini, Augusto Amici, Fabrizio Salomone, Giuseppe Fiume, Alessandro Rossetta, Enrico Gratton, Daniela Pozzi, Giulio Caracciolo Published in Scientific reports, May 2016 (see publication) Research themes: Liposomes and lipid nanoparticles Type: Paper

The protein corona of circulating PEGylated liposomes Sara Palchetti, Valentina Colapicchioni, Luca Digiacomo, Giulio Caracciolo, Daniela Pozzi, Anna Laura Capriotti, Giorgia La Barbera, Aldo Laganà Published in Biochimica et Biophysica Acta (BBA) - Biomembranes, February 2016 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

Stealth effect of biomolecular corona on nanoparticle uptake by immune cells Giulio Caracciolo, Sara Palchetti, Valentina Colapicchioni, Luca Digiacomo, Daniela Pozzi, Anna Laura Capriotti, Giorgia La Barbera, Aldo Laganà Published in Langmuir, October 2015 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: paper

The biomolecular corona of nanoparticles in circulating biological media Daniela Pozzi, Giulio Caracciolo, Luca Digiacomo, Valentina Colapicchioni, Sara Palchetti, Anna Laura Capriotti, Chiara Cavaliere, Riccardo Zenezini Chiozzi, Antonio Puglisi, Alado Laganà Published in Nanoscale, July 2015 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: paper

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