Giulio Caracciolo


Principal Investigator

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Curriculum Vitae

After humanistic education, I obtained my degree in Physics in 1999 followed by a PhD in Biophysics in 2003 at the Sapienza University of Rome (Italy) with an emphasis on the structure–activity relationship of cationic liposome/DNA complexes. Then I completed my postdoctoral formation at the synchrotron light source of Elettra (Trieste, Italy) and at the Laboratory for Fluorescence Dynamics, University of California at Irvine (CA, USA). I am currently Associate Professor of Medical Physics at the Molecular Medicine Department of the Sapienza University of Rome. My main interest is understanding the bio–nano interactions between drug and gene delivery systems and biological media. The relationships between synthetic identity, biological identity and physiological response of drug delivery systems will enable researchers to predict their physiological response after administration in vivo. This would represent a truly new paradigm in the field of pharmaceutics and nanomedicine. Another project deals with the exploitation of the nanoparticle-protein corona for early detection of cancer and other diseases.

Some publications with our group

Microfluidic Formulation of DNA-Loaded Multicomponent Lipid Nanoparticles for Gene Delivery
Erica Quagliarini, Serena Renzi, Luca Digiacomo, Francesca Giulimondi, Barbara Sartori, Heinz Amenitsch, Valentina Tassinari, Laura Masuelli, Roberto Bei, Lishan Cui, Junbiao Wang, Augusto Amici, Cristina Marchini, Daniela Pozzi, Giulio Caracciolo
Published in Pharmaceutics, August 2021 (see publication)
Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles
Type: Paper
Interplay of protein corona and immune cells controls blood residency of liposomes
Francesca Giulimondi, Luca Digiacomo, Daniela Pozzi, Sara Palchetti, Elisabetta Vulpis, Anna Laura Capriotti, Riccardo Zenezini Chiozzi, Aldo Laganà, Heinz Amenitsch, Laura Masuelli, Giovanna Peruzzi, Morteza Mahmoudi, Isabella Screpanti, Alessandra Zingoni, Giulio Caracciolo
Published in Nature communications, August 2019 (see publication)
Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles
Type: Paper
Converting the personalized biomolecular corona of graphene oxide nanoflakes into a high-throughput diagnostic test for early cancer detection
Massimiliano Papi, Valentina Palmieri, Luca Digiacomo, Francesca Giulimondi, Sara Palchetti, Gabriele Ciasca, Giordano Perini, Damiano Caputo, Maria Cristina Cartillone, Chiara Cascone, Roberto Coppola, Anna Laura Capriotti, Aldo Laganà, Daniela Pozzi, Giulio Caracciolo
Published in Nanoscale, July 2019 (see publication)
Research themes: Graphene Oxide and hybrid nanomaterials, Nanomaterials for cancer detection
Type: Paper
Disease-specific protein corona sensor arrays may have disease detection capacity
Giulio Caracciolo, Reihaneh Safavi-Sohi, Reza Malekzadeh, Hossein Poustchi, Mahdi Vasighi, Riccardo Zenezini Chiozzi, Anna Laura Capriotti, Aldo Laganà, Mohammad Hajipour, Marina Di Domenico, Angelina Di Carlo, Damiano Caputo, Haniyeh Aghaverdi, Massimiliano Papi, Valentina Palmieri, Angela Santoni, Sara Palchetti, Luca Digiacomo, Daniela Pozzi, Kenneth S Suslick, Morteza Mahmoudi
Published in Nanoscale Horizons, June 2019 (see publication)
Research themes: Liposomes and lipid nanoparticles, Nanomaterials for cancer detection
Type: Paper
Brain targeting by liposome–biomolecular corona boosts anticancer efficacy of temozolomide in glioblastoma cells
Antonietta Arcella, Sara Palchetti, Luca Digiacomo, Daniela Pozzi, Anna Laura Capriotti, Luigi Frati, Maria Antonietta Oliva, Georgia Tsaouli, Rossella Rota, Isabella Screpanti, Morteza Mahmoudi, Giulio Caracciolo
Published in ACS Chemical Neuroscience, July 2018 (see publication)
Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles
Type: Paper
Human biomolecular corona of liposomal doxorubicin: The overlooked factor in anticancer drug delivery
Giulio Caracciolo, Sara Palchetti, Luca Digiacomo, Riccardo Zenezini Chiozzi, Anna Laura Capriotti, Heinz Amenitsch, Paolo Maria Tentori, Valentina Palmieri, Massimiliano Papi, Francesco Cardarelli, Daniela Pozzi, Aldo Laganà
Published in ACS applied materials & interfaces, June 2018 (see publication)
Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles
Type: Paper
Manipulation of lipoplex concentration at the cell surface boosts transfection efficiency in hard-to-transfect cells
Sara Palchetti, Daniela Pozzi, Cristina Marchini, Augusto Amici, Cristina Andreani, Caterina Bartolacci, Luca Digiacomo, Valentina Gambini, Francesco Cardarelli, Carmine Di Rienzo, Giovanna Peruzzi, Heinz Amenitsch, Rocco Palermo, Isabella Screpanti, Giulio Caracciolo
Published in Nanomedicine: Nanotechnology, Biology and Medicine, February 2017 (see publication)
Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles
Type: Paper
Mechanistic evaluation of the transfection barriers involved in lipid-mediated gene delivery: interplay between nanostructure and composition
Daniela Pozzi, Cristina Marchini, Francesco Cardarelli, Fabrizio Salomone, Stefano Coppola, Maura Montani, Maria Elexpuru Zabaleta, Michelle A. Digman, Enrico Gratton, Valentina Colapicchioni, Giulio Caracciolo
Published in Biochimica et Biophysica Acta (BBA) - Biomembranes, March 2014 (see publication)
Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles
Type: paper
Selective targeting capability acquired with a protein corona adsorbed on the surface of 1, 2-dioleoyl-3-trimethylammonium propane/DNA nanoparticles
Giulio Caracciolo, Francesco Cardarelli, Daniela Pozzi, Fabrizio Salomone, Giuseppe Maccari, Giuseppe Bardi, Anna Laura Capriotti, Chiara Cavaliere, Massimiliano Papi, Aldo Laganà
Published in ACS applied materials & interfaces, December 2013 (see publication)
Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles
Type: paper