Francesco Cardarelli

We met Francesco in California where both of us were joining the Enrico Gratton’s Lab. Francesco is a biologist by training and a biophysicist by attitude who uses fluorescence spectroscopy to investigate complex biological processes at the cellular level. Together with Francesco we enjoy exploring the mechanisms of action of delivery systems and his support is fundamental to advance the delivery technologies developed in the Lab. Our football metaphors are amazing. "The Miro Klose of Fluorescence" was his first nickname. Nothing more correct.

Some publications with our group

Mechanistic Insights into the Release of Doxorubicin from Graphene Oxide in Cancer Cells Erica Quagliarini, Riccardo Di Santo, Daniela Pozzi, Paolo Tentori, Francesco Cardarelli, Giulio Caracciolo Published in Nanomaterials, August 2020 (see publication) Research themes: Nanocarriers for drug and gene delivery, Graphene Oxide and hybrid nanomaterials Type: Paper

A mechanistic explanation of the inhibitory role of the protein corona on liposomal gene expression Sara Palchetti, Luca Digiacomo, Francesca Giulimondi, Daniela Pozzi, Giovanna Peruzzi, Gianmarco Ferri, Heinz Amenitsch, Francesco Cardarelli, Morteza Mahmoudi, Giulio Caracciolo Published in Biochimica et Biophysica Acta (BBA) - Biomembranes, March 2020 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

Effect of Protein Corona on The Transfection Efficiency of Lipid-Coated Graphene Oxide-Based Cell Transfection Reagents Erica Quagliarini, Riccardo Di Santo, Sara Palchetti, Gianmarco Ferri, Francesco Cardarelli, Daniela Pozzi, Giulio Caracciolo Published in Pharmaceutics, February 2020 (see publication) Research themes: Nanocarriers for drug and gene delivery, Graphene Oxide and hybrid nanomaterials Type: Paper

Human biomolecular corona of liposomal doxorubicin: The overlooked factor in anticancer drug delivery Giulio Caracciolo, Sara Palchetti, Luca Digiacomo, Riccardo Zenezini Chiozzi, Anna Laura Capriotti, Heinz Amenitsch, Paolo Maria Tentori, Valentina Palmieri, Massimiliano Papi, Francesco Cardarelli, Daniela Pozzi, Aldo Laganà Published in ACS applied materials & interfaces, June 2018 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

Dynamic fingerprinting of sub-cellular nanostructures by image mean square displacement analysis Luca Digiacomo, Francesca D’autilia, William Durso, Paolo Maria Tentori, Giulio Caracciolo, Francesco Cardarelli Published in Scientific reports, November 2017 (see publication) Research themes: Nanocarriers for drug and gene delivery Type: Paper

An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles Luca Digiacomo, Francesco Cardarelli, Daniela Pozzi, Sara Palchetti, Michelle A. Digman, Enrico Gratton, Anna Laura Capriotti, Morteza Mahmoudi, Giulio Caracciolo Published in Nanoscale, October 2017 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

Manipulation of lipoplex concentration at the cell surface boosts transfection efficiency in hard-to-transfect cells Sara Palchetti, Daniela Pozzi, Cristina Marchini, Augusto Amici, Cristina Andreani, Caterina Bartolacci, Luca Digiacomo, Valentina Gambini, Francesco Cardarelli, Carmine Di Rienzo, Giovanna Peruzzi, Heinz Amenitsch, Rocco Palermo, Isabella Screpanti, Giulio Caracciolo Published in Nanomedicine: Nanotechnology, Biology and Medicine, February 2017 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper

The intracellular trafficking mechanism of Lipofectamine-based transfection reagents and its implication for gene delivery Francesco Cardarelli, Luca Digiacomo, Cristina Marchini, Augusto Amici, Fabrizio Salomone, Giuseppe Fiume, Alessandro Rossetta, Enrico Gratton, Daniela Pozzi, Giulio Caracciolo Published in Scientific reports, May 2016 (see publication) Research themes: Liposomes and lipid nanoparticles Type: Paper

Mechanistic evaluation of the transfection barriers involved in lipid-mediated gene delivery: interplay between nanostructure and composition Daniela Pozzi, Cristina Marchini, Francesco Cardarelli, Fabrizio Salomone, Stefano Coppola, Maura Montani, Maria Elexpuru Zabaleta, Michelle A. Digman, Enrico Gratton, Valentina Colapicchioni, Giulio Caracciolo Published in Biochimica et Biophysica Acta (BBA) - Biomembranes, March 2014 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: paper

Selective targeting capability acquired with a protein corona adsorbed on the surface of 1, 2-dioleoyl-3-trimethylammonium propane/DNA nanoparticles Giulio Caracciolo, Francesco Cardarelli, Daniela Pozzi, Fabrizio Salomone, Giuseppe Maccari, Giuseppe Bardi, Anna Laura Capriotti, Chiara Cavaliere, Massimiliano Papi, Aldo Laganà Published in ACS applied materials & interfaces, December 2013 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: paper

Mechanistic understanding of gene delivery mediated by highly efficient multicomponent envelope-type nanoparticle systems Daniela Pozzi, Cristina Marchini, Francesco Cardarelli, Alessandro Rossetta, Valentina Colapicchioni, Augusto Amici, Maura Montani, Stefania Motta, Paola Brocca, Laura Cantù, Giulio Caracciolo Published in Molecular pharmaceutics, December 2013 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: paper

Cholesterol-dependent macropinocytosis and endosomal escape control the transfection efficiency of lipoplexes in CHO living cells Francesco Cardarelli, Daniela Pozzi, Angelo Bifone, Cristina Marchini, Giulio Caracciolo Published in Molecular pharmaceutics, February 2012 (see publication) Research themes: Nanocarriers for drug and gene delivery, Liposomes and lipid nanoparticles Type: Paper